Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0809566 on October 30, 2009

Published online before print October 30, 2009
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(Journal of Leukocyte Biology. 2010;87:107-116.)
© 2010 Society for Leukocyte Biology

CD57+ T lymphocytes and functional immune deficiency

Daniele Focosi*,1, Marco Bestagno{dagger}, Oscar Burrone{dagger} and Mario Petrini*

* Division of Hematology, Azienda Ospedaliera Santa Chiara, University of Pisa, Pisa, Italy; and
{dagger} Molecular Immunoogy Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

1. Correspondence: Division of Hematology, Azienda Ospedaliera Santa Chiara, University of Pisa, via Roma 56, 56100 Pisa, Italy. E-mail: dfocosi{at}tin.it

CD57+ expression in T lymphocytes has been recognized for decades as a marker of in vitro replicative senescence. In recent years, accumulating evidences have pointed on the utility of this marker to measure functional immune deficiency in patients with autoimmune disease, infectious diseases, and cancers. We review here the relevant literature and implications in clinical settings.

Key Words: LEU7 • cancer • autoimmunity • immune senescence