Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0908542 on September 9, 2009

Published online before print September 9, 2009
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(Journal of Leukocyte Biology. 2009;86:1427-1437.)
© 2009 Society for Leukocyte Biology

CD4+CD25+ regulatory T cells attenuate hypersensitivity pneumonitis by suppressing IFN-{gamma} production by CD4+ and CD8+ T cells

Yuna Park1, Sae Jin Oh1 and Doo Hyun Chung2

Department of Pathology, Laboratory of Immune Regulation in Department of Biomedical Sciences, and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea

2. Correspondence: Department of Pathology and Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea. E-mail: doohyun{at}snu.ac.kr

ABSTRACT

HP results from the repeated inhalation of environmental antigens; however, the roles of CD4+CD25+ Treg cells in HP are unknown. Therefore, we investigated the functions of CD4+CD25+ Treg cells in SR-induced murine HP. More severe HP was observed in CD4+CD25+ Treg cell-depleted mice than in control mice in terms of histological alterations, inflammatory cell numbers in BALF, and the serum level of SR-specific IgG, which were restored by the adoptive transfer of CD4+CD25+ Treg cells. The CD4+CD25+ Treg cell-depleted mice also showed elevated levels of IFN-{gamma}, TGF-β, and reduced IL-4 production in the lungs. Moreover, IL-10 production of CD4+CD25+ Treg cells and direct contact between CD4+CD25+ Treg cells and CD4+ or CD8+ T cells in BALF resulted in reduced IFN-{gamma} production. Taken together, CD4+CD25+ Treg cells play a protective role in SR-induced HP by suppressing IFN-{gamma} production by T cells.

Key Words: Treg cells • suppression • IL-10 • INF-{gamma} • Saccharopolyspora recti-virgula