Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0609385 on September 9, 2009

Published online before print September 9, 2009
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Buy
Right arrow All Versions of this Article:
jlb.0609385v1
86/5/1065    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Solinas, G.
Right arrow Articles by Allavena, P.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solinas, G.
Right arrow Articles by Allavena, P.
(Journal of Leukocyte Biology. 2009;86:1065-1073.)
© 2009 Society for Leukocyte Biology

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

G. Solinas*, G. Germano*, A. Mantovani*,{dagger} and P. Allavena*,1

* Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy; and
{dagger} Department of Translational Medicine, University of Milan, Milan, Italy

1. Correspondence: Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano (MI), Italy. E-mail: paola.allavena{at}humanitas.it

The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.

Key Words: microenvironment • metastasis • angiogenesis • myeloid cells




This article has been cited by other articles:


Home page
 Cancer Res.Home page
G. Germano, R. Frapolli, M. Simone, M. Tavecchio, E. Erba, S. Pesce, F. Pasqualini, F. Grosso, R. Sanfilippo, P. G. Casali, et al.
Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells
Cancer Res., March 15, 2010; 70(6): 2235 - 2244.
[Abstract] [Full Text] [PDF]