Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0509368 on July 30, 2009

Published online before print July 30, 2009
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(Journal of Leukocyte Biology. 2009;86:803-812.)
© 2009 Society for Leukocyte Biology

Innate immune control and regulation of influenza virus infections

Jodi McGill, Jonathan W. Heusel and Kevin L. Legge1

Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA

1. Correspondence: Department of Pathology, 1036ML, 200 Hawkins Dr., Iowa City, IA 52242, USA. E-mail: kevin-legge{at}uiowa.edu

Adaptive immune responses are critical for the control and clearance of influenza A virus (IAV) infection. However, in recent years, it has become increasingly apparent that innate immune cells, including natural killer cells, alveolar macrophages (aM{phi}), and dendritic cells (DC) are essential following IAV infection in the direct control of viral replication or in the induction and regulation of virus-specific adaptive immune responses. This review will discuss the role of these innate immune cells following IAV infection, with a particular focus on DC and their ability to induce and regulate the adaptive IAV-specific immune response.

Key Words: NK cells • macrophages • dendritic cells




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