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Originally published online as doi:10.1189/jlb.0908581 on April 28, 2009

Published online before print April 28, 2009
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(Journal of Leukocyte Biology. 2009;86:617-623.)
© 2009 Society for Leukocyte Biology

Src family kinases are necessary for cell migration induced by extracellular HMGB1

Roberta Palumbo*,1, Francesco De Marchis*, Tobias Pusterla*,{dagger}, Antonio Conti*, Massimo Alessio* and Marco E. Bianchi{dagger}

* San Raffaele Research Institute and
{dagger} San Raffaele University, Faculty of Medicine, Milan, Italy

1. Correspondence: San Raffaele Research Institute, Genetics and Cell Biology, via Olgettina 58, 20132 Milano, Italy. E-mail: palumbo.roberta{at}hsr.it

ABSTRACT

HMGB1 is a nuclear protein that signals tissue damage, as it is released by cells dying traumatically or secreted by activated innate immunity cells. Extracellular HMGB1 elicits the migration to the site of tissue damage of several cell types, including inflammatory cells and stem cells. The identity of the signaling pathways activated by extracellular HMGB1 is not known completely: We reported previously that ERK and NF-{kappa}B pathways are involved, and we report here that Src is also activated. The ablation of Src or inhibition with the kinase inhibitor PP2 blocks migration toward HMGB1. Src associates to and mediates the phosphorylation of FAK and the formation of focal adhesions.

Key Words: chemokines • DAMP • danger signals • stem cells • tissue repair