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Originally published online as doi:10.1189/jlb.0808474 on December 16, 2008

Published online before print December 16, 2008
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(Journal of Leukocyte Biology. 2009;85:335-343.)
© 2009 by Society for Leukocyte Biology

Leukocyte trafficking in primary immunodeficiencies

Luigi D. Notarangelo*,1 and Raffaele Badolato{dagger}

* Division of Immunology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and
{dagger} Department of Pediatrics, University of Brescia, Brescia, Italy

1 Correspondence: Division of Immunology, Children’s Hospital, Harvard Medical School, Karp Family Building, 9th Floor, Room 9210, 1 Blackfan Circle, Boston, MA 02115, USA. E-mail: luigi.notarangelo{at}childrens.harvard.edu

Leukocyte recirculation through central and peripheral lymphoid organs and peripheral tissues is essential to maintain immune homeostasis. Some of the genetically determined, primary immunodeficiencies compromise leukocyte trafficking. Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-{gamma}-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome.

Key Words: adhesion deficiency • WHIM syndrome • Wiskott-Aldrich syndrome