Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0508281 on August 4, 2008

Published online before print August 4, 2008
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
jlb.0508281v1
84/6/1379    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Oostrom, M. C.
Right arrow Articles by Hoefer, I. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Oostrom, M. C.
Right arrow Articles by Hoefer, I. E.
(Journal of Leukocyte Biology. 2008;84:1379-1391.)
© 2008 by Society for Leukocyte Biology

Insights into mechanisms behind arteriogenesis: what does the future hold?

Melany C. van Oostrom*,1, Olivia van Oostrom{dagger},1, Paul H. A. Quax{ddagger},§, Marianne C. Verhaar{dagger} and Imo E. Hoefer*,2

* Experimental Cardiology and
{dagger} Vascular Medicine, University Medical Center Utrecht, The Netherlands;
{ddagger} Biosciences, TNO Quality of Life, Leiden, The Netherlands; and
§ Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

2 Correspondence: Laboratory of Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, Heidelberglaan 100, The Netherlands. E-mail: i.hoefer{at}umcutrecht.nl

Arteriogenesis, the enlargement of collateral vessels, seems a promising new target to improve blood flow to ischemic regions in patients suffering from cardiovascular conditions. With the growing knowledge of the mechanisms involved in arteriogenesis and the factors that influence the process, an increasing number of clinical trials are being performed to stimulate arteriogenesis, providing more insight in therapeutic opportunities for arteriogenesis. The expression of growth factors and the cooperation of surrounding and infiltrating cells seem to be essential in orchestrating the complex processes during arteriogenesis. In this review, we will discuss the regulating mechanisms of arteriogenesis, including the role of growth factors and different cell types and their implementation in a clinical setting. Furthermore, individual differences in the arteriogenic response will be considered, in light of the effect this will have on the success of therapeutic strategies to improve blood flow to ischemic tissue.

Key Words: growth factors • cell therapy




This article has been cited by other articles:


Home page
 Circ. Res.Home page
R. Kishore, P. Krishnamurthy, and D. W. Losordo
Career Moves: Induced Pluripotent Cells From Human Aortic Smooth Muscle Cells Can Efficiently Redifferentiate Into Parental Phenotype
Circ. Res., January 8, 2010; 106(1): 7 - 9.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. W. Millard and Y. Wang
Milieu interieur the search for myocardial arteriogenic signals.
J. Am. Coll. Cardiol., June 9, 2009; 53(23): 2148 - 2149.
[Full Text] [PDF]