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Originally published online as doi:10.1189/jlb.0807553 on June 10, 2008

Published online before print June 10, 2008
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(Journal of Leukocyte Biology. 2008;84:1223-1237.)
© 2008 by Society for Leukocyte Biology

Regulation of superoxide production in neutrophils: role of calcium influx

Sabrina Bréchard1 and Eric J. Tschirhart

Life Sciences Research Unit, University of Luxembourg, Luxembourg

1 Correspondence: Life Sciences Research Unit, University of Luxembourg, Avenue de la Faïencerie, L-1511 Luxembourg. E-mail: sabrina.brechard{at}uni.lu

Upon stimulation, activation of NADPH oxidase complexes in neutrophils produces a burst of superoxide anions contributing to oxidative stress and the development of inflammatory process. Store-operated calcium entry (SOCE), whereby the depletion of intracellular stores induces extracellular calcium influx, is known to be a crucial element of NADPH oxidase regulation. However, the mechanistic basis mediating SOCE is still only partially understood, as is the signal-coupling pathway leading to modulation of store-operated channels. This review emphasizes the role of calcium influx in the control of the NADPH oxidase and summarizes the current knowledge of pathways mediating this extracellular calcium entry in neutrophils. Such investigations into the cross-talk between NADPH oxidase and calcium might allow the identification of novel pharmacological targets with clinical use, particularly in inflammatory diseases.

Key Words: store-operated Ca2+ entry • NADPH oxidase • granulocytes