Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.1107773 on June 17, 2008

Published online before print June 17, 2008
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(Journal of Leukocyte Biology. 2008;84:981-987.)
© 2008 by Society for Leukocyte Biology

The essential role of the in situ immune reaction in human colorectal cancer

Franck Pagès*,{dagger},{ddagger},§, Jérôme Galon*,{dagger},{ddagger} and Wolf H. Fridman*,{dagger},{ddagger},§,1

* Centre de Recherche des Cordeliers, Université Paris Descartes, Paris, France;
{dagger} Université Pierre et Marie Curie-Paris6, Paris, France;
{ddagger} INSERM, Paris, France; and
§ Immunology Unit, Hopital Européen Georges Pompidou, Paris, France

1 Correspondence: Centre de Recherche des Cordeliers, UMRS 872, rue de l’Ecole de Médecine, Paris, F-75006 France. E-mail: herve.fridman{at}crc.jussieu.fr

ABSTRACT

Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically detectable human tumors escaping immune surveillance are no longer kept in check by the immune cells of the tumor microenvironment. Despite studies showing the influence of immune cell infiltrates on the behavior of colorectal carcinomas, this parameter is not currently recognized as a reliable prognostic factor. We showed that the nature, functional orientation, density, and location of immune cells within distinct tumor regions could provide a prognostic factor superior to and independent of criteria related to the anatomic extent of the tumor. The strength of the immune reaction identified in our studies could advance our understanding of cancer evolution and have important consequences for clinical practice.

Key Words: tumor immunology • memory T cells • prognostic factors






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