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Originally published online as doi:10.1189/jlb.0408256 on July 29, 2008

Published online before print July 29, 2008
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(Journal of Leukocyte Biology. 2008;84:1039-1046.)
© 2008 by Society for Leukocyte Biology

CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis

Bryan M. Burt, George Plitas, Jennifer A. Stableford, Hoang M. Nguyen, Zubin M. Bamboat, Venu G. Pillarisetty and Ronald P. DeMatteo1

Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

1 Correspondence: Memorial Sloan-Kettering Cancer Center, Box 203, 1275 York Avenue, New York, NY 10065, USA. E-mail: dematter{at}mskcc.org

ABSTRACT

The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1+CD3–) in the murine liver whose function was currently unknown. In naïve animals, CD11c+ liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c– liver NK cells. During the innate response to adenovirus infection, CD11c+ NK cells were the more common IFN-{gamma}-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-{gamma} production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c+ NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis.

Key Words: IFN-{gamma} • adenovirus • dendritic cells • Toll-like receptor 9 • hepatic




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