Journal of Leukocyte Biology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published online as doi:10.1189/jlb.0308211 on June 18, 2008

Published online before print June 18, 2008
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jlb.0308211v1
84/3/864    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Sousa, M. G. T.
Right arrow Articles by Almeida, S. R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sousa, M. G. T.
Right arrow Articles by Almeida, S. R.
(Journal of Leukocyte Biology. 2008;84:864-870.)
© 2008 by Society for Leukocyte Biology

Fonsecaea pedrosoi infection induces differential modulation of costimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis

Maria Glória Teixeira Sousa*, Conceição de Maria Pedrozo e Silva Azevedo{dagger}, Rosana Cicera Nascimento*, Eliver Eid Bou Ghosn*, Karla Leticia Santiago*, Vanessa Noal*, Gisele Facholi Bomfim*, Sirlei Garcia Marques{dagger}, Azizedite Guedes Gonçalves{dagger}, Daniel Wagner de Castro Lima Santos{dagger} and Sandro Rogerio Almeida*,1

{dagger} Departamento de Patologia, Universidade Federal do Maranhão, São Luís/Maranhão, Brazil; and
* Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil

1 Correspondence: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 580, Bloco 17, 05508-900, São Paulo, SP, Brazil. E-mail: sandroal{at}usp.br

ABSTRACT

The host defense mechanism in chromoblastomycosis has not been thoroughly investigated. It has been suggested that cell-mediated immunity in patients with long-standing chromoblastomycosis is somehow impaired. As a result, these individuals became unable to develop an efficient immune reaction. Many studies have shown that monocyte-derived macrophages exhibit critical activities in immunity to microorganisms. Moreover, the ability of cells from the monocytic lineage to process and present antigens, to produce cytokines, and to provide costimulatory signals confirms their pivotal role in the initiation of specific immune responses. In the present study, it was observed that monocytes from patients with a severe form of disease had a higher production of IL-10 and a lower expression of HLA-DR and costimulatory molecules when stimulated with specific antigen or LPS. Immune modulation with recombinant IL-12 or anti-IL-10 can restore the antigen-specific Th1-type immune response in chromoblastomycosis patients by up-regulating HLA-DR and costimulatory molecules in monocytes. Therefore, our data show that monocytes from patients with different clinical forms of chromoblastomycosis present distinct phenotypic and functional profiles. This observation suggests possible mechanisms that control the T cell response and influence their role in the development of pathology.

Key Words: immune regulation • Th1/Th2 • IL-12 • IL-10






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Society for Leukocyte Biology.