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Originally published online as doi:10.1189/jlb.1107770 on May 21, 2008

Published online before print May 21, 2008
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(Journal of Leukocyte Biology. 2008;84:614-622.)
© 2008 by Society for Leukocyte Biology

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don’t

Angela Dolganiuc1 and Gyongyi Szabo

Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

1 Correspondence: Department of Medicine/Gastroeneterology Division, University of Massachusetts Medical School, LRB 270J, 364 Plantation St., Worcester, MA 01605, USA. E-mail: angela.dolganiuc{at}umassmed.edu

ABSTRACT

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

Key Words: Tr1 • Th3 • CD8+ Tregs • FoxP3 • IL-10 • TGF-β • liver