Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0807578 on December 21, 2007

Published online before print December 21, 2007
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(Journal of Leukocyte Biology. 2008;83:640-647.)
© 2008 by Society for Leukocyte Biology

Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines

Nicolas Kesteman*, Georgette Vansanten*, Bernard Pajak*, Sanna M. Goyert{dagger} and Muriel Moser*,1

* Université Libre de Bruxelles, Institut de Biologie et Médecine Moléculaires, Gosselies, Belgium; and
{dagger} North Shore University Hospital/New York University School of Medicine, Manhasset, New York, USA

1Correspondence: Laboratoire de Physiologie Animale, Université Libre de Bruxelles, Rue des Prof. Jeener et Brachet, 12, 6041 Gosselies, Belgium. E-mail: mmoser{at}ulb.ac.be

There is increasing evidence that neutrophils are involved in the regulation of adaptive immunity. We therefore tested whether these cells may colocalize with T lymphocytes in lymphoid organs. Our results demonstrate that administration of the microbial product LPS induces the migration of neutrophils in the spleen from the red pulp and the marginal zone to the area of the white pulp where T cells reside. This movement is CD14-dependent, whereas the recruitment of neutrophils in the peritoneal cavity is increased in the absence of CD14. Our data further suggest the involvement of the chemokine MIP-2 and keratinocyte-derived chemokine and their receptor CXCR2. We conclude that neutrophils may interact with naïve T cells upon infection/inflammation and that the migration of neutrophils in the lymphoid organs and in the periphery is regulated differently by a signal transduced by CD14

Key Words: cell trafficking • KC • MIP-2 • LIX • dendritic cells




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