Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.0407215 on December 13, 2007

Published online before print December 13, 2007
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(Journal of Leukocyte Biology. 2008;83:564-574.)
© 2008 by Society for Leukocyte Biology

Loss of function in virus-specific lung effector T cells is independent of infection

Subhashini Arimilli, Ellen M. Palmer and Martha A. Alexander-Miller1

Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

1Correspondence: Department of Microbiology and Immunology, Room 5053, Hanes Building, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. E-mail: marthaam{at}wfubmc.edu

ABSTRACT

Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus-specific CD8+ effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed to be the result of infection-induced changes in the lung. Although virus-specific effects may contribute to regulation of T cells in the lung, the findings from this study provide evidence that the basal lung environment is sufficient to promote loss of function in effector cells. Loss of function occurs within 48 h of entry into the lung and is most evident in cells residing in the lung parenchyma. These findings suggest an additional paradigm for the immunoregulation of effector cells that enter the lung as a result of virus infection.

Key Words: CTL • regulation • CD8 • respiratory tract




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R. B. Fulton, M. R. Olson, and S. M. Varga
Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs
J. Virol., August 15, 2008; 82(16): 7799 - 7811.
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