PeproTech Inc.
Originally published online as doi:10.1189/jlb.0507281 on November 2, 2007

Published online before print November 2, 2007
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jlb.0507281v1
83/2/254    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ndhlovu, L. C.
Right arrow Articles by Hecht, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ndhlovu, L. C.
Right arrow Articles by Hecht, F. M.
(Journal of Leukocyte Biology. 2008;83:254-262.)
© 2008 by Society for Leukocyte Biology

FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection

Lishomwa C. Ndhlovu*,1, Christopher P. Loo*, Gerald Spotts{dagger}, Douglas F. Nixon*,2 and Frederick M. Hecht{dagger},2

* Division of Experimental Medicine and
{dagger} Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA

1 Correspondence: Division of Experimental Medicine, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA. E-mail: lishomwa.ndhlovu{at}ucsf.edu

ABSTRACT

During the course of HIV-1 infection, the status of immune activation has been determined to be a powerful indicator of disease progression. The immune system has adopted self-regulatory mechanisms to counterbalance undesirable immune responses. CD25+CD4+ T regulatory (Treg) cells that express the transcription regulator, forkhead box P3 (FOXP3), play an important role in this immunosuppression. Using a combination of Treg cell discriminatory markers (FOXP3, CD25, CD127), we predicted that an expansion of Treg cell subsets would negatively correlate with immune activation during the early stages of HIV-1 infection. We report that FOXP3+CD127lo expressing CD4+ T cells increases in primary HIV-1 infection over time. Furthermore, the FOXP3+CD127lo CD4+ T cells may, in fact, reduce the levels of T cell activation following primary infection. It is interesting that the positive correlation between FOXP3+CD127lo CD4+ and CD25+CD127lo CD4+ T cells noted in HIV-uninfected persons is not only lost but may also be reversed in early, chronic HIV-1 infection. Unlike FOXP3+CD127lo CD4+, the level of FOXP3+CD25+CD127lo CD4+ T cells did not correlate with T cell activation, suggesting that these cells were not effective in reducing T cell activation. These observations suggest that different Treg populations may have different effects on reducing immune activation in HIV-1 infection and that the FOXP3+CD127lo CD4+ T cell population may be particularly important in limiting immune activation.

Key Words: regulation • immunosuppression • viral • AIDS




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
R. Simone, A. Zicca, and D. Saverino
The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age
J. Leukoc. Biol., December 1, 2008; 84(6): 1454 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. J. Chase, H.-C. Yang, H. Zhang, J. N. Blankson, and R. F. Siliciano
Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation
J. Virol., September 1, 2008; 82(17): 8307 - 8315.
[Abstract] [Full Text] [PDF]