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Originally published online as doi:10.1189/jlb.0707504 on October 25, 2007

Published online before print October 25, 2007
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(Journal of Leukocyte Biology. 2008;83:237-244.)
© 2008 by Society for Leukocyte Biology

Roles of T lymphocytes in pulmonary fibrosis

Irina G. Luzina, Nevins W. Todd, Aldo T. Iacono and Sergei P. Atamas1

University of Maryland School of Medicine and Baltimore VA Medical Center, Baltimore, Maryland, USA

1 Correspondence: University of Maryland School of Medicine, 10 South Pine Street, MSTF 8-34, Baltimore, MD 21201, USA. E-mail: satamas{at}umaryland.edu

Infiltration of T lymphocytes in the lungs is common in patients with and in animal models of pulmonary fibrosis. The role of these cells in regulating the accumulation of extracellular matrix, particularly collagen, is not understood completely. Research literature provides evidence for a profibrotic, an antifibrotic, or no significant role of T lymphocytes in pulmonary fibrosis. This review offers a discussion of such evidence with the focus on phenotypes of pulmonary T lymphocytes and related profibrotic and antifibrotic mechanisms. It appears unlikely that T lymphocytic infiltration per se is the central driving force in most cases of pulmonary fibrosis. Instead, evidence suggests that T lymphocytes may modulate the inflammatory and healing responses in the lungs in a profibrotic or antifibrotic manner, depending on their phenotype. Phenotypic reshaping, rather than elimination of the infiltrating pulmonary T lymphocytes, may be a promising approach to improving outcomes in patients with pulmonary fibrosis.

Key Words: lung • collagen • inflammation




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