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Published online before print October 10, 2007

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(Journal of Leukocyte Biology. 2008;83:71-79.)
© 2008 by Society for Leukocyte Biology

Differential expression of β₂-integrins and cytokine production between and β T cells in experimental autoimmune encephalomyelitis

Sherry S. Smith^* and Scott R. Barnum^*,,1

Departments of
^* Microbiology and
Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA

¹ Correspondence: Department of Microbiology, University of Alabama at Birmingham, 845 19th St. S., BBRB/842, Birmingham, AL 35294, USA. E-mail: sbarnum{at}uab.edu

ABSTRACT

The expression of β₂-integrins on T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared β₂-integrin expression and cytokine production between and β T cells over the acute course of EAE. We observed that unlike in β T cells, β₂-integrin expression on T cells increased significantly from baseline, peaked at Day 10, and remained unchanged in the draining lymph nodes or declined in the spleen and CNS by Day 15. In addition, IFN-- and TNF--producing T cells infiltrated the CNS rapidly and produced significantly more of these cytokines than β T cells throughout the course of EAE. These results suggest unique roles for β₂-integrins in the trafficking of versus β T cells during EAE and that T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease.

Key Words: adhesion molecules • demyelinating disease • neuroimmunology