Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.0307137 on September 28, 2007

Published online before print September 28, 2007
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(Journal of Leukocyte Biology. 2008;83:165-172.)
© 2008 by Society for Leukocyte Biology

A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Yoshiko Kagimoto*,{dagger}, Hisakata Yamada*, Takahiro Ishikawa*, Naoyoshi Maeda{ddagger}, Fumi Goshima§, Yukihiro Nishiyama§, Masutaka Furue{dagger} and Yasunobu Yoshikai*,1

* Division of Host Defense, Medical Institute of Bioregulation,
{dagger} Department of Dermatology, Graduate School of Medicine,
{ddagger} Digital Medicine Initiative, Kyushu University, Fukuoka, Japan; and
§ Department of Virology, Nagoya University School of Medicine, Nagoya, Japan

1 Correspondence: Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: yoshikai{at}bioreg.kyushu-u.ac.jp

IL-15 plays a critical role in the development and maturation of {gamma}{delta} intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-β1 upon TCR triggering than in control mice. In vivo neutralization of TGF-β ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-β1, promoting wound healing but impeding protection against genital HSV-2 infection.

Key Words: {gamma}{delta} T cells • immunity • immune regulation • cytokines






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