Vancouver
Originally published online as doi:10.1189/jlb.0307137 on September 28, 2007

Published online before print September 28, 2007
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
jlb.0307137v1
83/1/165    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kagimoto, Y.
Right arrow Articles by Yoshikai, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kagimoto, Y.
Right arrow Articles by Yoshikai, Y.
(Journal of Leukocyte Biology. 2008;83:165-172.)
© 2008 by Society for Leukocyte Biology

A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Yoshiko Kagimoto*,{dagger}, Hisakata Yamada*, Takahiro Ishikawa*, Naoyoshi Maeda{ddagger}, Fumi Goshima§, Yukihiro Nishiyama§, Masutaka Furue{dagger} and Yasunobu Yoshikai*,1

* Division of Host Defense, Medical Institute of Bioregulation,
{dagger} Department of Dermatology, Graduate School of Medicine,
{ddagger} Digital Medicine Initiative, Kyushu University, Fukuoka, Japan; and
§ Department of Virology, Nagoya University School of Medicine, Nagoya, Japan

1 Correspondence: Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: yoshikai{at}bioreg.kyushu-u.ac.jp

IL-15 plays a critical role in the development and maturation of {gamma}{delta} intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-β1 upon TCR triggering than in control mice. In vivo neutralization of TGF-β ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-β1, promoting wound healing but impeding protection against genital HSV-2 infection.

Key Words: {gamma}{delta} T cells • immunity • immune regulation • cytokines




This article has been cited by other articles:


Home page
 J. Virol.Home page
N. Gill and A. A. Ashkar
Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2
J. Virol., January 15, 2009; 83(2): 918 - 926.
[Abstract] [Full Text] [PDF]