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Originally published online as doi:10.1189/jlb.0607338 on August 20, 2007

Published online before print August 20, 2007
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(Journal of Leukocyte Biology. 2007;82:1375-1381.)
© 2007 by Society for Leukocyte Biology

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Philippe Van Lint1 and Claude Libert2

Departments of Molecular Biomedical Research, VIB, and Molecular Biology, Ghent University, Ghent, Belgium

2Correspondence: VIB, Ghent University, Technologiepark 927, Ghent (Zwijnaarde), East-Flanders 9052, Belgium. E-mail: claude.libert{at}dmbr.ugent.be

The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

Key Words: extracellular matrix • ELR




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