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Originally published online as doi:10.1189/jlb.0307167 on July 18, 2007

Published online before print July 18, 2007
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(Journal of Leukocyte Biology. 2007;82:861-868.)
© 2007 by Society for Leukocyte Biology

Bidirectional MHC molecule exchange between migratory and resident dendritic cells

Magali de Heusch*, Didier Blocklet{dagger}, Dominique Egrise{dagger}, Bernard Hauquier{dagger}, Marjorie Vermeersch*, Serge Goldman{dagger} and Muriel Moser*,1

* Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, Gosselies, Belgium; and
{dagger} Hopital Erasme, Université Libre de Bruxelles, Brussels, Belgium

1 Correspondence: Laboratoire de Physiologie Animale, Université Libre de Bruxelles, Rue des Prof. Jeener et Brachet, 12, 6041 Gosselies, Belgium. E-mail: mmoser{at}ulb.ac.be

Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules and that a proportion of injected DCs acquired host MHC molecules. These observations suggest that a bidirectional MHC molecule exchange occurs between migratory and resident DCs, a mechanism that may amplify antigen presentation in vivo.

Key Words: antigen presentation • expression • interaction • migration • lymph nodes




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