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Published online before print April 24, 2007

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(Journal of Leukocyte Biology. 2007;82:300-310.)
© 2007 by Society for Leukocyte Biology

Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3^–/– mice

F. L. Oliveira^*, P. Frazão^*, R. Chammas^,1, D. K. Hsu, F. T. Liu, R. Borojevic^*, C. M. Takiya^* and M. C. El-Cheikh^*,1,2

^* Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;
Laboratório de Oncologia Experimental, Faculdade de Medicina da Universidade de São Paulo, and Center for Cell-Based Therapy, CEPID-FAPESP, São Paulo, Brazil; and
Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA

² Correspondence: Universidade Federal do Rio de Janeiro, Av. Pau-Brasil, s/n, 21949-900 Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil. E-mail: marcia{at}histo.ufrj.br

ABSTRACT

Galectin-3 (gal-3), a β-galactoside-binding animal lectin, plays a role in cell-cell and cell-extracellular matrix interactions. Extracellular gal-3 modulates cell migration and adhesion in several physiological and pathological processes. Gal-3 is highly expressed in activated macrophages. Schistosoma mansoni eggs display a large amount of gal-3 ligands on their surface and elicit a well-characterized, macrophage-dependent, granulomatous, inflammatory reaction. Here, we have investigated the acute and chronic phases of S. mansoni infection in wild-type and gal-3^–/– mice. In the absence of gal-3, chronic-phase granulomas were smaller in diameter, displaying thinner collagen fibers with a loose orientation. Schistosoma-infected gal-3^–/– mice had remarkable changes in the monocyte/macrophage, eosinophil, and B lymphocyte subpopulations as compared with the infected wild-type mice. We observed a reduction of macrophage number, an increase in eosinophil absolute number, and a decrease in B lymphocyte subpopulation (B220^+/high cells) in the periphery during the evolution of the disease in gal-3^–/– mice. B lymphopenia was followed by an increase of plasma cell number in bone marrow, spleen, and mesenteric lymph nodes of the infected gal-3^–/– mice. The plasma IgG and IgE levels also increased in these mice. Gal-3 plays a role in the organization, collagen distribution, and mobilization of inflammatory cells to chronic-phase granulomas, niches for extramedullary myelopoiesis, besides interfering with monocyte-to-macrophage and B cell-to-plasma cell differentiation.

Key Words: Schistosoma mansoni • plasma cells • macrophages • granuloma

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