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Originally published online as doi:10.1189/jlb.0207109 on April 11, 2007 Originally published online as doi:10.1189/jlb.0207109 on March 30, 2007

Published online before print March 30, 2007
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(Journal of Leukocyte Biology. 2007;81:1335-1344.)
© 2007 by Society for Leukocyte Biology

Rapid transit in the immune cells: the role of mRNA turnover regulation

Khalid S. A. Khabar1

Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

1 Correspondence: Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, P3354, mBC-03, Riyadh 11211, Saudi Arabia. E-mail: khabar{at}kfshrc.edu.sa

There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Post-transcriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.

Key Words: mRNA stability • post-trancriptional regulation • cytokines




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