Published online before print December 28, 2006

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(Journal of Leukocyte Biology. 2007;81:593-598.)
© 2007 by Society for Leukocyte Biology

An eye’s view of T regulatory cells

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

¹ Correspondence: Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA. E-mail: joan.stein{at}schepens.harvard.edu

T regulatory (Treg) cells have been studied for more than 30 years. Recently, changing technology and attitudes have led to new interest in T cell regulation of the immune responses. The eye is an immune-privileged site with unique mechanisms for the prevention of damaging immune inflammation. The eye fashions its Treg cells in novel ways to prevent immune inflammation locally and systemically. The purpose of this mini-review is to condense and summarize reports of Treg cells dependent on the eye in the context of the Treg literature in general.

Key Words: immune regulation • TGF-ß • ACAID

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