Published online before print November 29, 2006
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK; and Clinical Cooperation Group, Inflammatory Lung Diseases, GSF and Asklepios-Kliniken, Gauting, Germany
1 Correspondence: Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, LE1 9HN, UK. E-mail: lzh1{at}le.ac.uk
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16– and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.
Key Words: cytokines • migration • HIV • arthritis • atherosclerosis
This article has been cited by other articles:
 |
|
 |
|
  K. S. Rogacev, C. Ulrich, L. Blomer, F. Hornof, K. Oster, M. Ziegelin, B. Cremers, Y. Grenner, J. Geisel, A. Schlitt, et al. Monocyte heterogeneity in obesity and subclinical atherosclerosis Eur. Heart J., February 1, 2010; 31(3): 369 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Stubbs, A. Idiculla, J. Slusser, R. Menard, and L. D. Quarles Cholecalciferol Supplementation Alters Calcitriol-Responsive Monocyte Proteins and Decreases Inflammatory Cytokines in ESRD J. Am. Soc. Nephrol., February 1, 2010; 21(2): 353 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Ingersoll, R. Spanbroek, C. Lottaz, E. L. Gautier, M. Frankenberger, R. Hoffmann, R. Lang, M. Haniffa, M. Collin, F. Tacke, et al. Comparison of gene expression profiles between human and mouse monocyte subsets Blood, January 21, 2010; 115(3): e10 - e19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. N Jabbour, K. J Sales, R. D Catalano, and J. E Norman Inflammatory pathways in female reproductive health and disease Reproduction, December 1, 2009; 138(6): 903 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Soehnlein, L. Lindbom, and C. Weber Mechanisms underlying neutrophil-mediated monocyte recruitment Blood, November 19, 2009; 114(21): 4613 - 4623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Rogacev, M. Ziegelin, C. Ulrich, S. Seiler, M. Girndt, D. Fliser, and G. H. Heine Haemodialysis-induced transient CD16+ monocytopenia and cardiovascular outcome Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3480 - 3486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Gautier, C. Jakubzick, and G. J. Randolph Regulation of the Migration and Survival of Monocyte Subsets by Chemokine Receptors and Its Relevance to Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1412 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. K. Swirski, R. Weissleder, and M. J. Pittet Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1424 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Bradshaw, K. Raddassi, W. Elyaman, T. Orban, P. A. Gottlieb, S. C. Kent, and D. A. Hafler Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells J. Immunol., October 1, 2009; 183(7): 4432 - 4439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Serbina, M. Cherny, C. Shi, S. A. Bleau, N. H. Collins, J. W. Young, and E. G. Pamer Distinct Responses of Human Monocyte Subsets to Aspergillus fumigatus Conidia J. Immunol., August 15, 2009; 183(4): 2678 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tsujioka, T. Imanishi, H. Ikejima, A. Kuroi, S. Takarada, T. Tanimoto, H. Kitabata, K. Okochi, Y. Arita, K. Ishibashi, et al. Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction. J. Am. Coll. Cardiol., July 7, 2009; 54(2): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. G. Evans, N. J. Gullick, S. Kelly, C. Pitzalis, G. M. Lord, B. W. Kirkham, and L. S. Taams In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses PNAS, April 14, 2009; 106(15): 6232 - 6237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mosig, K. Rennert, S. Krause, J. Kzhyshkowska, K. Neunubel, R. Heller, and H. Funke Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+CD16+ monocytes in detoxification of oxidized LDL FASEB J, March 1, 2009; 23(3): 866 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Selkirk, T. M. McLellan, H. E. Wright, and S. G. Rhind Expression of intracellular cytokines, HSP72, and apoptosis in monocyte subsets during exertional heat stress in trained and untrained individuals Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R575 - R586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M E Wildenberg, J M C Welzen-Coppens, C G van Helden-Meeuwsen, H Bootsma, A Vissink, N van Rooijen, J P van de Merwe, H A Drexhage, and M A Versnel Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjogren syndrome Ann Rheum Dis, March 1, 2009; 68(3): 420 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Landsman, L. Bar-On, A. Zernecke, K.-W. Kim, R. Krauthgamer, E. Shagdarsuren, S. A. Lira, I. L. Weissman, C. Weber, and S. Jung CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival Blood, January 22, 2009; 113(4): 963 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Timmerman, M. G. Flynn, P. M. Coen, M. M. Markofski, and B. D. Pence Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise? J. Leukoc. Biol., November 1, 2008; 84(5): 1271 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Heron, J. C. Grutters, H. van Velzen-Blad, M. Veltkamp, A. M. E. Claessen, and J. M. M. van den Bosch Increased Expression of CD16, CD69, and Very Late Antigen-1 on Blood Monocytes in Active Sarcoidosis Chest, November 1, 2008; 134(5): 1001 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mancino, T. Schioppa, P. Larghi, F. Pasqualini, M. Nebuloni, I-H. Chen, S. Sozzani, J. M. Austyn, A. Mantovani, and A. Sica Divergent effects of hypoxia on dendritic cell functions Blood, November 1, 2008; 112(9): 3723 - 3734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Junttila, K. Mizukami, H. Dickensheets, M. Meier-Schellersheim, H. Yamane, R. P. Donnelly, and W. E. Paul Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4R{alpha}, IL-13R{alpha}1, and {gamma}c regulates relative cytokine sensitivity J. Exp. Med., October 27, 2008; 205(11): 2595 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nahrendorf, F. K. Swirski, E. Aikawa, L. Stangenberg, T. Wurdinger, J.-L. Figueiredo, P. Libby, R. Weissleder, and M. J. Pittet The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions J. Exp. Med., November 26, 2007; 204(12): 3037 - 3047. [Abstract] [Full Text] [PDF]
|
|
