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Published online before print August 29, 2006

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(Journal of Leukocyte Biology. 2007;81:41-45.)
© 2007 by Society for Leukocyte Biology

Pivotal Advances: High-mobility group box 1 protein—a cytokine with a role in cardiac repair

Antonia Germani^*, Federica Limana^* and Maurizio C. Capogrossi^,1

^* Laboratorio di Biologia Vascolare e Terapia Genica, Centro Cardiologico Fondazione Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy; and
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

¹Correspondence: Laboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata-IDI-IRCCS, Rome, Italy. E-mail: capogrossi{at}idi.it

ABSTRACT

The nuclear protein high-mobility group box 1 (HMGB1) has been largely characterized for its role in inflammation. However, HMGB1 released by inflammatory cells, as well as by necrotic cells, may also act as a signal of tissue damage and participate in tissue repair by recruiting stem cells to the injury site. The emergence of this function has focused the interest on HMGB1 as a molecule with an active role in tissue regeneration. We recently demonstrated that HMGB1 administration in a mouse model of myocardial infarction activates cardiac stem cells and promotes their differentiation into cardiomyocytes. The regenerative effect results in the improvement of cardiac function. In this review, we highlight the beneficial role of HMGB1 and discuss growth factor-based therapeutic approaches for the treatment of myocardial infarction.

Key Words: stem cells • infarction

Related Article

Interview with Dr. Maurizio C. Capogrossi regarding Pivotal Advance: High-mobility group box 1 protein—a cytokine with a role in cardiac repair

Helene F. Rosenberg and Joost J. Oppenheim
J. Leukoc. Biol. 2007 81: 38-40. [Full Text] [PDF]