HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print September 7, 2006

This Article Full Text Full Text (PDF) All Versions of this Article: jlb.0606409v1 81/1/144    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ralainirina, N. Articles by Zimmer, J. Search for Related Content PubMed PubMed Citation Articles by Ralainirina, N. Articles by Zimmer, J.

(Journal of Leukocyte Biology. 2007;81:144-153.)
© 2007 by Society for Leukocyte Biology

Control of NK cell functions by CD4⁺CD25⁺ regulatory T cells

Natacha Ralainirina^*, Aurélie Poli^*, Tatiana Michel^*, Linda Poos^*, Emmanuel Andrès, François Hentges^* and Jacques Zimmer^*,1

^* Laboratoire d’Immunogénétique-Allergologie, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg-City, Luxembourg; and
Service de Médecine Interne, Clinique Médicale B, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

¹Correspondence: Laboratoire d’Immunogénétique-Allergologie, Centre de Recherche Public de la Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. E-mail: jacques.zimmer{at}crp-sante.lu

Regulatory T cells (Treg) are key players in the maintenance of peripheral tolerance. As a result of suppressive effects on CD4⁺ and CD8⁺ effector T cells, Treg control the adaptive immune system and prevent autoimmunity. In addition, they inhibit B lymphocytes, dendritic cells, and monocytes/macrophages. It is interesting that several recent papers show that CD4⁺CD25⁺ Treg are also able to inhibit NK cells. Thus, Treg exert their control on immune responses from the onset (triggering of innate immune cells) to the effector phase of adaptive immunity (B and T cell-mediated responses). That Treg inhibit NK cells suggests that their uncontrolled activation might break self-tolerance and induce "innate" autoimmune pathology. Conversely, Treg-mediated suppression of NK cell functions might have negative effects, as these cells are important in defense against infections and cancer. It is conceivable that Treg might dampen efficient activation of NK cells in these diseases.

Key Words: suppression • inhibition • TGF-ß • NKG2D

This article has been cited by other articles:

				H. Yano, T. Ishida, A. Inagaki, T. Ishii, J. Ding, S. Kusumoto, H. Komatsu, S. Iida, H. Inagaki, and R. Ueda Defucosylated Anti CC Chemokine Receptor 4 Monoclonal Antibody Combined with Immunomodulatory Cytokines: A Novel Immunotherapy for Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome Clin. Cancer Res., November 1, 2007; 13(21): 6494 - 6500. [Abstract] [Full Text] [PDF]

				J. N. Beilke and R. G. Gill Frontiers in Nephrology: The Varied Faces of Natural Killer Cells in Transplantation Contributions to Both Allograft Immunity and Tolerance J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2262 - 2267. [Abstract] [Full Text] [PDF]