Journal of Leukocyte Biology BioLegend: Treg, Th17, Stem Cell
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Originally published online as doi:10.1189/jlb.0506305 on September 22, 2006

Published online before print September 22, 2006
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(Journal of Leukocyte Biology. 2006;80:1345-1353.)
© 2006 by Society for Leukocyte Biology

Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms

Pramod S. Joshi*, Jin-Qing Liu*, Yin Wang*, Xing Chang*, John Richards*, Erika Assarsson{dagger}, Fu-Dong Shi{ddagger}, Hans-Gustaf Ljunggren{dagger} and Xue-Feng Bai*,1

* Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA;
{dagger} Center for Infectious Medicine, Department of Medicine, Karolinska Institute, F59, Karolinska University Hospital Huddinge, Stockholm, Sweden; and
{ddagger} Barrow Neurological Institute, NRC-428, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA

1 Correspondence: Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA. E-mail: xue-feng.bai{at}osumc.edu

Cytokine-induced killer (CIK) cells are ex vivo, expanded T cells with proven anticancer activity in vitro and in vivo. However, their functional properties with the exception of their cancer cell-killing activity are largely unclear. Here, we show that CIK T cells recognize dendritic cells (DC), and although mature DC (mDC) induce CIK T cells to produce IFN-{gamma}, immature DC (iDC) are killed selectively by them. Moreover, CIK T cell activation by mDC and their destruction of iDC are independent of the TCR. The cytotoxicity of CIK T cells to iDC is perforin-dependent. Our data have revealed an important regulatory role of CIK cells.

Key Words: cytotoxicity • IFN-{gamma} • dendritic cells






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