Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published online as doi:10.1189/jlb.0306176 on August 2, 2006

Published online before print August 2, 2006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jlb.0306176v1
80/4/797    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldmann, J.
Right arrow Articles by Bechmann, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldmann, J.
Right arrow Articles by Bechmann, I.
(Journal of Leukocyte Biology. 2006;80:797-801.)
© 2006 by Society for Leukocyte Biology

T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa

Jana Goldmann*,{dagger}, Erik Kwidzinski*,{dagger}, Christine Brandt*, Jacqueline Mahlo*,{dagger}, Daniel Richter* and Ingo Bechmann*,{dagger},1

* Center for Anatomy, Institute of Cell Biology and Neurobiology, Department of Experimental Neuroimmunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; and
{dagger} Institute of Clinical Neuroanatomy, J. W. Goethe-University, Frankfurt/Main, Germany

1 Correspondence: Institute of Clinical Neuroanatomy, J. W. Goethe-University, Theodor-Stern-Kai 7, Frankfurt/Main 60 590, Germany, E-mail: Bechmann{at}med.uni-frankfurt.de

ABSTRACT

Although drainage pathways of soluble antigens from brain to cervical lymph nodes have been well established, there is no direct evidence for similar routes of leukocytes leaving the central nervous system. We developed a protocol allowing the cross-sectioning of an entire head-neck preparation while preserving the signal of the GFP. We monitored how GFP-expressing CD4 T lymphocytes injected into the entorhinal cortex after lesion or the lateral ventricle of unlesioned C57/bl6 mice reach cervical lymph nodes. Irrespective of the injection site, we demonstrate their passage through the cribroid plate, appearance in the nasal mucosa, and specific accumulation in one of the cervical lymph nodes.

Key Words: CNS • cell trafficking • immune tolerance






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Society for Leukocyte Biology.