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Originally published online as doi:10.1189/jlb.1105656 on July 24, 2006

Published online before print July 24, 2006
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(Journal of Leukocyte Biology. 2006;80:705-713.)
© 2006 by Society for Leukocyte Biology

Dual role of macrophages in tumor growth and angiogenesis

Chrystelle Lamagna*,{dagger}, Michel Aurrand-Lions* and Beat A. Imhof*,1

* Department of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland; and
{dagger} Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Fransico, California

1 Correspondence: Department of Pathology and Immunology, Centre Médical Universitaire, 1204, Geneva, Switzerland. E-mail: Beat.Imhof{at}medecine.unige.ch

ABSTRACT

During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of escaping the immune machinery. As the immune surveillance is not sufficient anymore, tumor-associated macrophages contribute to tumor progression. It is notable that tumor-associated macrophages promote the proliferation of tumor cells directly by secreting growth factors. They also participate in tumor progression by acting on endothelial cells and thus promoting the neovascularization of the tumor. Tumor-associated macrophages are indeed key protagonists during angiogenesis and promote each step of the angiogenesis cascade.

Key Words: chemokines • neovascularization • monocytes




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