Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.0506309 on August 3, 2006

Published online before print August 3, 2006
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(Journal of Leukocyte Biology. 2006;80:677-681.)
© 2006 by Society for Leukocyte Biology

The bone marrow constitutes a reservoir of pericyte progenitors

Chrystelle Lamagna and Gabriele Bergers1

Department of Neurological Surgery, Brain Tumor Research Center and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California

1 Correspondence: University of California San Francisco, Department of Neurological Surgery, 513 Parnassus Avenue, San Francisco, CA 94143-0520. E-mail: gabriele.bergers{at}ucsf.edu

ABSTRACT

Adult bone marrow is a rich reservoir of hematopoietic and mesenchymal stem and progenitor cells. Mobilization and recruitment of bone marrow-derived cells to injured or ischemic tissue or tumors endorse the initiation and maintenance of angiogenic processes in the adult by incorporating endothelial progenitor cells (EPC) into the developing vasculature and by recruiting accessory hematopoietic cells. Recent data have now revealed that the origin of bone marrow-derived vascular cells is not restricted to endothelial cells but also includes pericytes—the perivascular support cells. Several laboratories have now reported the existence of pericyte progenitor cells, and these cells, like EPC, can be mobilized and recruited to the remodeling vasculature under ischemic conditions and in tumors. This review focuses on pericytes in vessel formation and on recent discoveries about their bone marrow origin in the adult.

Key Words: tumor • PDGFR-ß • angiogenesis • pericytes




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