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Originally published online as doi:10.1189/jlb.0206123 on June 12, 2006

Published online before print June 12, 2006
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(Journal of Leukocyte Biology. 2006;80:237-244.)
© 2006 by Society for Leukocyte Biology

The central role of adrenomedullin in host defense

Enrique Zudaire1, Sergio Portal-Núñez and Frank Cuttitta

Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

1Correspondence: Cell and Cancer Biology Branch, NCI, NIH, Bldg. 10, Room 13N262, Bethesda, MD 20892. E-mail: zudairee{at}mail.nih.gov

Thirteen years after the isolation of adrenomedullin (AM) from a human pheochromocytoma, the literature is awash with reports describing its implication in countless physiological and disease mechanisms ranging from vasodilatation to cancer promotion. A growing body of evidence illustrates AM as a pivotal component in normal physiology and disease with marked beneficial effects in the host defense mechanism. Exogenous administration of AM as well as its ectopic overexpression and the use of drugs, which potentiates its activity, are promising strategies for treatment of septic shock and several other pathogen-related disorders. Although major progress toward this end has been achieved over the past few years, our further understanding of the pleiotropic mechanisms involved with AM as a protective peptide is paramount to maximize its clinical application.

Key Words: PAMP • AMBP-1 • septic shock




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