Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.0705382 on November 21, 2005

Published online before print November 21, 2005
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(Journal of Leukocyte Biology. 2006;79:294-302.)
© 2006 by Society for Leukocyte Biology

Phagocytosis stimulates mobilization and shedding of intracellular CD16A in human monocytes and macrophages: inhibition by HIV-1 infection

Nicole L. Webster*,{dagger},1, Katherine Kedzierska*,{ddagger}, Rula Azzam*,§, Geza Paukovics*, John Wilson, Suzanne M. Crowe*,§ and Anthony Jaworowski*,§

* AIDS Pathogenesis Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia; Departments of
{dagger} Immunology and
§ Medicine, Monash University, Melbourne, Australia;
{ddagger} Department of Microbiology and Immunology, University of Melbourne, Australia; and
Respiratory Unit, The Alfred Hospital, Melbourne, Australia

1Correspondence: AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Rd., Melbourne 3004, Australia. E-mail: nwebster{at}burnet.edu.au

Surface and intracellular staining coupled with flow cytometric analysis was used to show for the first time that human macrophages and a minor subset of peripheral blood monocytes have an internal pool of CD16A, which is mobilized and shed during Fc receptor for immunoglobulin G-mediated phagocytosis. Human immunodeficiency virus type 1 (HIV-1) infection of monocyte-derived macrophages in vitro led to a reduction in the phagocytosis-induced up-regulation in CD16A shedding. These results suggest that monocytes and macrophages may be a source of soluble CD16A, which is elevated in the serum of patients in a variety of disease states and that the mobilization and shedding of CD16A in response to phagocytosis are disrupted by HIV-1 infection.

Key Words: soluble CD16 • Fc{gamma}R • immunoglobulin G • soluble Fc{gamma}RIII • monocyte subsets




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N. L. Webster and S. M. Crowe
Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases
J. Leukoc. Biol., November 1, 2006; 80(5): 1052 - 1066.
[Abstract] [Full Text] [PDF]


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