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Originally published online as doi:10.1189/jlb.0105040 on November 10, 2005

Published online before print November 10, 2005
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(Journal of Leukocyte Biology. 2006;79:36-39.)
© 2006 by Society for Leukocyte Biology

CD16+ monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data

George Soares, Aldina Barral, Jackson M. Costa, Manoel Barral-Netto and Johan Van Weyenbergh1

LIMI, LIP, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil; and Institute for Immunological Investigation, São Paulo-SP, Brazil

1 Correspondence: FIOCRUZ, LIMI-CPqGM, Rua Waldemar Falcão 121, 40295-001 Salvador-BA, Brazil. E-mail: johan{at}cpqgm.fiocruz.br

Peripheral blood CD16 (Fc receptor for immunoglobulin G III)-positive monocytes have been shown to expand in different pathological conditions, such as cancer, asthma, sepsis, human immunodeficiency virus infection, and AIDS progression, but data in leishmaniasis are lacking. We found that cutaneous leishmaniasis patients (n=15) displayed a significant increase in the percentage (3.5 vs. 10.1) as well as mean fluorescent intensity (13.5 vs. 29.2) of ex vivo CD16 expression in monocytes as compared with healthy controls. We observed a significant positive correlation between the percentage of ex vivo CD16+ monocytes and lesion size (P=0.0052, r=0.75) or active transforming growth factor-ß plasma levels (P=0.0017, r=0.78). In addition, two patients with nonhealing lesions during a 3-year follow-up had high (9.1–19.4%) CD16 levels at diagnosis. Our data suggest a deleterious role for CD16 in human leishmaniasis, as well as its possible use as a marker for disease severity and/or adverse disease outcome.

Key Words: Leishmania • TGF-ß • Fc receptor • whole blood • lesion size




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