Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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Originally published online as doi:10.1189/jlb.1004601 on October 21, 2005

Published online before print October 21, 2005
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(Journal of Leukocyte Biology. 2006;79:166-172.)
© 2006 by Society for Leukocyte Biology

Ceramide catabolism critically controls survival of human dendritic cells

Luigi Franchi1, Florence Malisan, Barbara Tomassini and Roberto Testi2

Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine, University of Rome "Tor Vergata," Italy

2 Correspondence: Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine, University of Rome "Tor Vergata," via Montpellier 1, 00133 Rome, Italy. E-mail: roberto.testi{at}uniroma2.it

The regulation of dendritic cell (DC) survival is crucial for the modulation of adaptive immunity. Ceramide is a lipid mediator of the stress response, which accumulates intracellularly during DC differentiation. We found that ceramide levels are tightly regulated in human DCs and that the pharmacological inhibition of enzymes responsible for ceramide catabolism, such as ceramidases and sphingosine kinases, sensitizes DCs to ceramide-induced cell death. It is important that inhibition of sphingosine kinases, during lipopolysaccharide stimulation, causes extensive ceramide accumulation and death of DCs. These data indicate that ceramide catabolism regulates survival of human DCs and reveal novel potential targets for the pharmacological manipulation of the immune response.

Key Words: LPS • ceramidases • sphingosine kinases




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