science pharmaceutical expo biotech jobs
Originally published online as doi:10.1189/jlb.0705397 on October 4, 2005

Published online before print October 4, 2005
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jlb.0705397v1
79/1/16    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iannello, A.
Right arrow Articles by Ahmad, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iannello, A.
Right arrow Articles by Ahmad, A.
(Journal of Leukocyte Biology. 2006;79:16-35.)
© 2006 by Society for Leukocyte Biology

Viral strategies for evading antiviral cellular immune responses of the host

Alexandre Iannello, Olfa Debbeche, Elodie Martin, Lynda Habiba Attalah, Suzanne Samarani and Ali Ahmad1

Laboratory of Immunovirology, Ste-Justine Hospital Research Center, Department of Microbiolgy and Immunology, University of Montreal, Quebec, Canada

1 Correspondence: Laboratory of Immunovirology, Ste-Justine Hospital Research Center, 3175 Cote Ste Catherine, Montreal, Quebec, H3T 1C5, Canada. E-mail: ali.ahmad{at}recherche-ste-justine.qc.ca

The host invariably responds to infecting viruses by activating its innate immune system and mounting virus-specific humoral and cellular immune responses. These responses are aimed at controlling viral replication and eliminating the infecting virus from the host. However, viruses have evolved numerous strategies to counter and evade host’s antiviral responses. Providing specific examples from the published literature, we discuss in this review article various strategies that viruses have developed to evade antiviral cellular responses of the host. Unraveling these viral strategies allows a better understanding of the host-pathogen interactions and their coevolution. This knowledge is important for identifying novel molecular targets for developing antiviral reagents. Finally, it may also help devise new knowledge-based strategies for developing antiviral vaccines.

Key Words: antigen presentation • CTL • NK cells • MHC antigens • viral infections




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A.-C. Iversen, B. Steinkjer, N. Nilsen, J. Bohnhorst, S. H. Moen, R. Vik, P. Stephens, D. W. Thomas, C. A. Benedict, and T. Espevik
A Proviral Role for CpG in Cytomegalovirus Infection
J. Immunol., May 1, 2009; 182(9): 5672 - 5681.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Majumder, N. J. Venkatachari, S. O'Leary, and V. Ayyavoo
Infection with Vpr-Positive Human Immunodeficiency Virus Type 1 Impairs NK Cell Function Indirectly through Cytokine Dysregulation of Infected Target Cells
J. Virol., July 15, 2008; 82(14): 7189 - 7200.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS
J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination
J. Leukoc. Biol., July 1, 2008; 84(1): 27 - 49.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
K. Kiryluk, J. Martino, and A. G. Gharavi
Genetic Susceptibility, HIV Infection, and the Kidney
Clin. J. Am. Soc. Nephrol., July 1, 2007; 2(Supplement_1): S25 - S35.
[Abstract] [Full Text] [PDF]