Published online before print October 4, 2005
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T cells in the lung
* Departments of Immunology,
Pediatrics, Division of Cell Biology, and
¶ Medicine, National Jewish Medical and Research Center, Denver, Colorado;
Department of Pediatrics, Chungbuk National University and College of Medicine, Cheongju, Korea; and
California National Primate Research Center, University of California, Davis
1Correspondence: Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206. E-mail: bornw{at}njc.org
Pulmonary 
T cells protect the lung and its functions, but little is known about their distribution in this organ and their relationship to other pulmonary cells. We now show that and 
ß T cells are distributed differently in the normal mouse lung. The T cells have a bias for nonalveolar locations, with the exception of the airway mucosa. Subsets of T cells exhibit further variation in their tissue localization. and ß T cells frequently contact other leukocytes, but they favor different cell-types. The T cells show an intrinsic preference for F4/80+ and major histocompatibility complex class II+ leukocytes. Leukocytes expressing these markers include macrophages and dendritic cells, known to function as sentinels of airways and lung tissues. The continuous interaction of T cells with these sentinels likely is related to their protective role.
Key Words: T cell receptor • T cell subsets • mouse
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