Published online before print August 4, 2005

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(Journal of Leukocyte Biology. 2005;78:879-887.)
© 2005 by Society for Leukocyte Biology

In vivo rescue of defective memory CD8⁺ T cells by cognate helper T cells

Department of Microbiology, University of Tennessee, Knoxville

¹Correspondence: M409 Department of Microbiology, University of Tennessee, Knoxville, TN 37996; Department of Microbiology, James Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614. E-mail: udayk@utk.edu and btr{at}utk.edu

The magnitude and efficacy of CD8⁺ T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4⁺ help. This report demonstrates that this CD8⁺ memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The inability of adoptive transfer of memory SIINFEKL-specific CD8 cells to reject tumors was overcome if recipients were primed for ovalbumin-specific helper cell responses. Additionally, animals primed for a SIINFEKL-specific memory response and incapable of rejecting the tumor could regain protective immunity if given helper cells. This pattern of CD8⁺ T cell functional rescue or reprogramming by helper cell transfer was replicated using a Herpes simplex virus antiviral immunity system. Our results could mean that therapeutic vaccine approaches could be designed to compensate situations that have defective CD8⁺ T cell function.

Key Words: vaccine • HSV

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