Published online before print March 17, 2005
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,1
* Griffith University, Queensland, Australia; and
Institute for Molecular Bioscience, CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, The University of Queensland, Australia
1 Correspondence: IMB, The University of Queensland, St. Lucia, Queensland, Australia 4072. E-mail: D.Hume{at}imb.uq.edu.au
An effective immune system requires rapid and appropriate activation of inflammatory mechanisms but equally rapid and effective resolution of the inflammatory state. A review of the canonical host response to gram-negative bacteria, the lipopolysaccharide-Toll-like receptor 4 signaling cascade, highlights the induction of repressors that act at each step of the activation process. These inflammation suppressor genes are characterized by their induction in response to pathogen, typically late in the macrophage activation program, and include an expanding class of dominant-negative proteins derived from alternate splicing of common signaling components. Despite the expanse of anti-inflammatory mechanisms available to an activated macrophage, the frailty of this system is apparent in the large numbers of genes implicated in chronic inflammatory diseases. This apparent lack of redundancy between inflammation suppressor genes is discussed with regard to evolutionary benefits in generating a heterogeneous population of immune cells and consequential robustness in defense against new and evolving pathogens.
Key Words: Toll-like receptor • lipopolysaccharide • macrophage
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