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Published online before print May 17, 2005

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(Journal of Leukocyte Biology. 2005;78:80-84.)
© 2005 by Society for Leukocyte Biology

Cooperation between platelet-derived CD154 and CD4⁺ T cells for enhanced germinal center formation

Bennett D. Elzey^*, Julieann F. Grant^,, Haley W. Sinn^*, Bernhard Nieswandt, Thomas J. Waldschmidt^, and Timothy L. Ratliff^*,,¶,,**,,1

^* Departments of Urology,
Pathology, Interdisciplinary Immunology Program, and
^** Microbiology,
Carver College of Medicine, Medical Scientist Training Program,
^¶ Prostate Cancer Research Group, and
Holden Comprehensive Cancer Center, University of Iowa, Iowa City;
Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany; and
Iowa City Veterans Affairs Medical Center, Iowa City

¹ Correspondence: University of Iowa, Department of Urology, 3206 MERF, 375 Newton Road, Iowa City, IA 52242. E-mail: tim-ratliff{at}uiowa.edu

ABSTRACT

It has been demonstrated previously that platelet-derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154^–/– mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet-derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen-specific CD4⁺ T cell numbers are limiting. We propose that in the physiologic setting where antigen-specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity.

Key Words: B cells • humoral immunity • mouse • innate immunity • knockout

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