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Originally published online as doi:10.1189/jlb.0105049 on March 30, 2005

Published online before print March 30, 2005
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(Journal of Leukocyte Biology. 2005;78:37-42.)
© 2005 by Society for Leukocyte Biology

Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects

Anthony Kebba*,{dagger},1, Justin Stebbing*, Samantha Rowland*,{dagger}, Rebecca Ingram*,{dagger}, John Agaba{dagger}, Steve Patterson*, Pontiano Kaleebu{dagger}, Nesrina Imami* and Frances Gotch*

* Department of Immunology, Imperial College, Chelsea & Westminster Hospital, London, United Kingdom; and
{dagger} Medical Research Council Programme on AIDS in Uganda, Uganda Virus Research Institute, Entebbe

1 Correspondence: Department of Immunology, Imperial College, Chelsea & Westminster Hospital, 369 Fulham Rd., London SW10 9NH, UK. E-mail: a.kebba{at}ic.ac.uk

The significantly higher surface expression of the surface heat-shock protein receptor CD91 on monocytes of human immunodeficiency virus type-1 (HIV-1)-infected, long-term nonprogressors suggests that HIV-1 antigen uptake and cross-presentation mediated by CD91 may contribute to host anti-HIV-1 defenses and play a role in protection against HIV-1 infection. To investigate this further, we performed phenotypic analysis to compare CD91 surface expression on CD14+ monocytes derived from a cohort of HIV-1-exposed seronegative (ESN) subjects, their seropositive (SP) partners, and healthy HIV-1-unexposed seronegative (USN) subjects. The median fluorescent intensity (MFI) of CD91 on CD14+ monocytes was significantly higher in ESN compared with SP (P=0.028) or USN (P=0.007), as well as in SP compared with USN subjects (P=0.018). CD91 MFI was not normalized in SP subjects on highly active antiretroviral therapy (HAART) despite sustainable, undetectable plasma viraemia. Data in three SP subjects experiencing viral rebounds following interruption of HAART showed low CD91 MFI comparable with levels in USN subjects. There was a significant positive correlation between CD91 MFI and CD8+ T cell counts in HAART-naïve SP subjects (r=0.7, P=0.015). Increased surface expression of CD91 on CD14+ monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects.

Key Words: CD14+ monocytes • HIV-1 • exposed sero-negative • CD91 • CD14+ monocytes




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