HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print April 21, 2005

This Article Full Text Full Text (PDF) All Versions of this Article: jlb.0604341v1 78/1/114    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, X. Articles by Howard, O. M. Z. Search for Related Content PubMed PubMed Citation Articles by Chen, X. Articles by Howard, O. M. Z.

(Journal of Leukocyte Biology. 2005;78:114-121.)
© 2005 by Society for Leukocyte Biology

BALB/c mice have more CD4⁺CD25⁺ T regulatory cells and show greater susceptibility to suppression of their CD4⁺CD25^– responder T cells than C57BL/6 mice

Xin Chen^*,1, Joost J. Oppenheim and O. M. Zack Howard

^* Basic Research Program, SAIC-Frederick, Inc., and
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Maryland

¹ Correspondence: Basic Research Program, SAIC-Frederick, Inc., P.O. Box B, Bldg. 560, Rm. 31-19, Frederick, MD 21702-1201. E-mail: xinc{at}ncifcrf.gov

Increasing evidence indicates that CD4⁺CD25⁺ T regulatory (Treg) cells control a wide spectrum of immune responses. The initial identification of CD4⁺CD25⁺ Treg cell as a "professional suppressor" was based on observations made in BALB/c mice. This mouse strain is well known to preferentially develop T helper cell type 2 responses, to be more susceptible to intracellular parasite infection, to have a higher tumor incidence, and to be more resistant to the induction of autoimmune diseases, as compared with C57BL/6 (B6) mice. We therefore decided to compare Treg cell function of B6 and BALB/c mice. We observed that the frequency of CD4⁺CD25⁺ T cells in the thymus and peripheral lymphoid organs of BALB/c mice was higher than in B6 mice. CD4⁺CD25⁺ Treg cells from both mouse strains shared similar phenotypic properties, including expression of characteristic immunological markers and hyporesponsiveness to T cell receptor cross-linking and in their capacity to suppress proliferation of BALB/c CD4⁺CD25^– T responder (Tres) cells. However, CD4⁺CD25^– Tres cells from B6 mice were notably less susceptible to suppression by CD4⁺CD25⁺ Treg cells from either mouse strain. Our data suggest that the number and the level of suppression of CD4⁺CD25⁺ Treg cells for CD4⁺CD25^– Tres cells may be dictated by genetic background. Our data also suggest that differences in the CD4⁺CD25⁺ Treg cell number and the susceptibility of CD4⁺CD25^– Tres cells may, at least in part, account for the differences in immune response between B6 and BALB/c strains of mice.

Key Words: rodent • T lymphocytes • tolerance/suppression/anergy

This article has been cited by other articles:

				K. F. Siemasko, J. Gao, V. L. Calder, R. Hanna, M. Calonge, S. C. Pflugfelder, J. Y. Niederkorn, and M. E. Stern In Vitro Expanded CD4+CD25+Foxp3+ Regulatory T Cells Maintain a Normal Phenotype and Suppress Immune-Mediated Ocular Surface Inflammation Invest. Ophthalmol. Vis. Sci., December 1, 2008; 49(12): 5434 - 5440. [Abstract] [Full Text] [PDF]

				N. Geudens, M. Van de Wouwer, B. M. Vanaudenaerde, R. Vos, C. Van De Wauwer, G. M. Verleden, E. Verbeken, T. Lerut, D. E. M. Van Raemdonck, and E. M. Conway The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury Eur. Respir. J., October 1, 2008; 32(4): 862 - 870. [Abstract] [Full Text] [PDF]

				D. K. Y. Ang, T. C. Brodnicki, M. A. Jordan, W. E. Wilson, P. Silveira, B. L. Gliddon, A. G. Baxter, and I. R. van Driel Two genetic loci independently confer susceptibility to autoimmune gastritis Int. Immunol., September 1, 2007; 19(9): 1135 - 1144. [Abstract] [Full Text] [PDF]

				S. Roque, C. Nobrega, R. Appelberg, and M. Correia-Neves IL-10 Underlies Distinct Susceptibility of BALB/c and C57BL/6 Mice to Mycobacterium avium Infection and Influences Efficacy of Antibiotic Therapy J. Immunol., June 15, 2007; 178(12): 8028 - 8035. [Abstract] [Full Text] [PDF]

				T. Lambe, J. C. H. Leung, H. Ferry, T. Bouriez-Jones, K. Makinen, T. L. Crockford, H. R. Jiang, J. M. Nickerson, L. Peltonen, J. V. Forrester, et al. Limited Peripheral T Cell Anergy Predisposes to Retinal Autoimmunity J. Immunol., April 1, 2007; 178(7): 4276 - 4283. [Abstract] [Full Text] [PDF]

				D. R. Sekiguchi, L. Yunk, D. Gary, D. Charan, B. Srivastava, D. Allman, M. G. Weigert, and E. T. L. Prak Development and Selection of Edited B Cells in B6.56R Mice. J. Immunol., June 1, 2006; 176(11): 6879 - 6887. [Abstract] [Full Text] [PDF]

				J. Y. Niederkorn, M. E. Stern, S. C. Pflugfelder, C. S. De Paiva, R. M. Corrales, J. Gao, and K. Siemasko Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal Keratoconjunctivitis J. Immunol., April 1, 2006; 176(7): 3950 - 3957. [Abstract] [Full Text] [PDF]

				A. Rijnierse, A. S. Koster, F. P. Nijkamp, and A. D. Kraneveld Critical Role for Mast Cells in the Pathogenesis of 2,4-Dinitrobenzene-Induced Murine Colonic Hypersensitivity Reaction J. Immunol., April 1, 2006; 176(7): 4375 - 4384. [Abstract] [Full Text] [PDF]