| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Published online before print January 3, 2005
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Microbiology and Immunology, University of South Alabama, Mobile
1 Correspondence: Department of Microbiology and Immunology, MSB 2096, University of South Alabama, Mobile, AL 36607. E-mail: rlausch{at}jaguar1.usouthal.edu
Analogous to CD4+ T cells, neutrophils are essential participants in delayed-type hypersensitivity (DTH) to Herpes simplex virus type 1 antigen. However, what role they play in this cellular immune response is unclear. The recent recognition that neutrophils are potent producers of chemokines led us to hypothesize that they may help recruit CD4+ effector T cells. In the present study, we show that neutrophil depletion was accompanied by a marked decrease in the numbers of CD4+ and CXC receptor 3+ (CXCR3+)-expressing cells migrating to the DTH site and a sharp drop in the levels of interferon-inducible protein 10 (IP-10) and monokine induced by IFN-
(Mig). Purified mouse neutrophils were stimulated directly by IFN- to secrete these chemokines, and neutrophils at the DTH site expressed IP-10. IFN- knockout mice, which manifested depressed ear-swelling following DTH challenge, made little IP-10 and no Mig. Reconstitution of these mice with IFN- induced CXCR3 ligand synthesis. Depletion of neutrophils or CD4+ T cells but not CD8+ T cells markedly reduced IFN- levels, suggesting the former were direct (or indirect) cellular sources of this cytokine. Collectively, our results support the hypothesis that neutrophil production of T cell-recruiting chemokines contributes to the regulation and amplification of the DTH response.
Key Words: T lymphocyte
This article has been cited by other articles:
|
|
 |
|
  K. Flanagan, Z. Modrusan, J. Cornelius, A. Chavali, I. Kasman, L. Komuves, L. Mo, and L. Diehl Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion J. Immunol., March 15, 2008; 180(6): 3874 - 3881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tamassia, V. Le Moigne, F. Calzetti, M. Donini, S. Gasperini, T. Ear, A. Cloutier, F. O. Martinez, M. Fabbri, M. Locati, et al. The MYD88-Independent Pathway Is Not Mobilized in Human Neutrophils Stimulated via TLR4 J. Immunol., June 1, 2007; 178(11): 7344 - 7356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Sabroe, L. C. Parker, D. H. Dockrell, D. E. Davies, S. K. Dower, and M. K. B. Whyte Targeting the Networks that Underpin Contiguous Immunity in Asthma and Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 306 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shiratsuchi, T. Iyoda, N. Tanimoto, D. Kegai, K. Nagata, and Y. Kobayashi Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production J. Leukoc. Biol., February 1, 2007; 81(2): 412 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Navarini, M. Recher, K. S. Lang, P. Georgiev, S. Meury, A. Bergthaler, L. Flatz, J. Bille, R. Landmann, B. Odermatt, et al. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses PNAS, October 17, 2006; 103(42): 15535 - 15539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Sheng, S. Hu, H. T. Ni, T. N. Rowen, J. R. Lokensgard, and P. K. Peterson TNF-{alpha}-induced chemokine production and apoptosis in human neural precursor cells J. Leukoc. Biol., December 1, 2005; 78(6): 1233 - 1241. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
