Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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Originally published online as doi:10.1189/jlb.0404262 on December 23, 2004

Published online before print December 23, 2004
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(Journal of Leukocyte Biology. 2005;77:513-521.)
© 2005 by Society for Leukocyte Biology

CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines

Claudia Sandoval-Montes and Leopoldo Santos-Argumedo1

Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados, I.P.N., México

1 Correspondence: Departamento de Biomedicina Molecular, CINVESTAV-IPN, Av. IPN #2508, Col. Zacatenco, Apartado Postal 14-740, CP 07360, México, D.F., México. E-mail: lesantos{at}cinvestav.mx

CD38 is an ~45-kDa type II transmembrane glycoprotein expressed by hematopoietic and nonhematopoietic cells. Its surface expression is under complex control and varies during lymphocyte development, activation, and differentiation, suggesting an important role in these processes. Murine CD38 has been mainly characterized on B lymphocytes, and in humans, the molecule has been studied in T cells. This paper provides evidences that murine CD38 is regulated tightly during T cell activation and differentiation. On the periphery, a subset of mature T lymphocytes was identified by the expression of CD38. These cells showed an activated phenotype; they were larger and more granular than their negative counterparts. In accord with this observation, in vitro-activated T cells up-regulated CD38. Memory T lymphocytes also were CD38-positive. It is interesting that T cells expressing high levels of CD38 had a reduced, proliferative capacity but displayed an improved potential to produce interleukin-2 and interferon-{gamma}, suggesting a role of this molecule during T cell activation and differentiation.

Key Words: subpopulations • naïve • memory • T lymphocytes




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