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Originally published online as doi:10.1189/jlb.0204096 on October 21, 2004

Published online before print October 21, 2004
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(Journal of Leukocyte Biology. 2005;77:67-70.)
© 2005 by Society for Leukocyte Biology

Human V{gamma}9/V{delta}2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)

Matthias Eberl*,1, Rosel Engel*, Silke Aberle{dagger}, Paul Fisch{dagger}, Hassan Jomaa* and Hanspeter Pircher{ddagger}

* Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Germany; and
{dagger} Pathologisches Institut, Molekulare Pathologie, and
{ddagger} Institut für Medizinische Mikrobiologie und Hygiene, Immunologie, Albert-Ludwigs-Universität Freiburg, Germany

1 Correspondence: Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. E-mail: matthias.eberl{at}biochemie.med.uni-giessen.de

The killer cell lectin-like receptor G1 (KLRG1) is expressed in natural killer (NK) cells and effector memory {alpha}ß T cells. {gamma}{delta} T cells represent an unconventional lymphocyte population that shares characteristics of NK cells and T cells and links innate and adaptive immunity. V{gamma}9/V{delta}2 T cells comprise the majority of peripheral human {gamma}{delta} T cells and respond to the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Here, we demonstrate that KLRG1 is expressed in a significant proportion of V{gamma}9/V{delta}2 T cells in cord blood and in the majority of peripheral V{gamma}9/V{delta}2 T cells from adult donors. KLRG1+ V{gamma}9/V{delta}2 T cells displayed an effector memory phenotype, as KLRG1 was expressed mainly in V{gamma}9/V{delta}2 T cells lacking CD27, CD45RA, CD62L, and CC chemokine receptor 7 (CCR7). Unlike {alpha}ß T cells, where possession of KLRG1 identified effector memory cells with impaired proliferative capacity, KLRG1+ V{gamma}9/V{delta}2 T cells were able to proliferate vigorously upon stimulation with HMB-PP in the presence of interleukin-2. Moreover, KLRG1 ligation on V{gamma}9/V{delta}2 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells.

Key Words: {gamma}{delta} T lymphocytes • memory • killer inhibitory receptors • senescence • CD94




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