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Published online before print October 21, 2004

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(Journal of Leukocyte Biology. 2005;77:67-70.)
© 2005 by Society for Leukocyte Biology

Human V9/V2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)

Matthias Eberl^*,1, Rosel Engel^*, Silke Aberle, Paul Fisch, Hassan Jomaa^* and Hanspeter Pircher

^* Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Germany; and
Pathologisches Institut, Molekulare Pathologie, and
Institut für Medizinische Mikrobiologie und Hygiene, Immunologie, Albert-Ludwigs-Universität Freiburg, Germany

¹ Correspondence: Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. E-mail: matthias.eberl{at}biochemie.med.uni-giessen.de

The killer cell lectin-like receptor G1 (KLRG1) is expressed in natural killer (NK) cells and effector memory ß T cells. T cells represent an unconventional lymphocyte population that shares characteristics of NK cells and T cells and links innate and adaptive immunity. V9/V2 T cells comprise the majority of peripheral human T cells and respond to the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Here, we demonstrate that KLRG1 is expressed in a significant proportion of V9/V2 T cells in cord blood and in the majority of peripheral V9/V2 T cells from adult donors. KLRG1⁺ V9/V2 T cells displayed an effector memory phenotype, as KLRG1 was expressed mainly in V9/V2 T cells lacking CD27, CD45RA, CD62L, and CC chemokine receptor 7 (CCR7). Unlike ß T cells, where possession of KLRG1 identified effector memory cells with impaired proliferative capacity, KLRG1⁺ V9/V2 T cells were able to proliferate vigorously upon stimulation with HMB-PP in the presence of interleukin-2. Moreover, KLRG1 ligation on V9/V2 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells.

Key Words: T lymphocytes • memory • killer inhibitory receptors • senescence • CD94

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