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Published online before print September 15, 2004

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(Journal of Leukocyte Biology. 2004;76:1134-1141.)
© 2004 by Society for Leukocyte Biology

Differential expression and function of IgA receptors (CD89 and CD71) during maturation of dendritic cells

Benoit Pasquier^*, Yves Lepelletier, Cédric Baude, Olivier Hermine and Renato C. Monteiro^*,1

^* INSERM E0225, Bichat Medical School, Paris, France; and
CNRS UMR8147, Necker Hospital, Paris, France

¹ Correspondence: Bichat Medical School, 16, Rue Henri Huchard, BP 416, 75870 Paris Cedex 18, France. E-mail: monteiro{at}bichat.inserm.fr

Dendritic cells (DC) are the most efficient antigen-presenting cells residing in mainly peripheral tissues. Antigen uptake by DC is particularly efficient, being mediated by various receptors such as lectin, scavenger receptors, and Fc receptors (FcRs). Immunoglobulin A (IgA) is part of the first-line immune barrier in mucosae, where DC are numerous. A member of the FcR family, FcRI, is expressed on interstitial DC. We report here that monocyte-derived DC (Mo-DC) express another IgA receptor (IgA-R), the transferrin receptor (TfR), even in the absence of DC proliferation in vitro. Upon incubation with inflammatory cytokines such as tumor necrosis factor and interleukin (IL)-1ß or maturating agents (lipopolysaccharide, CD40 ligand), FcRI and TfR expression on Mo-DC was specifically up-regulated, whereas FcRs and FcRI expression was down-regulated. Both IgA-Rs were functional, being able to mediate endocytosis by immature and activated Mo-DC. Although FcRI internalized IgA complexes on both types of DC, TfR was only able to mediate IgA complex internalization by immature cells. Cross-linking of FcRI but not of TfR resulted in up-regulation of major histocompatibility complex (MHC) class II/CD86 expression and secretion of IL-10 and IL-12 by immature Mo-DC. Moreover, in activated Mo-DC, cross-linking of FcRI could up-regulated MHC class II/CD86 and triggered IL-10 secretion. Our findings led us to propose that FcRI expressed by interstitial-type DC could play a critical role to sample IgA-recognized antigens and also during DC activation.

Key Words: Fc receptor • transferrin receptor • dendritic cells

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