Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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Originally published online as doi:10.1189/jlb.0204085 on July 26, 2004

Published online before print July 26, 2004
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(Journal of Leukocyte Biology. 2004;76:835-844.)
© 2004 by Society for Leukocyte Biology

Antisecretory factor expression is regulated by inflammatory mediators and influences the severity of experimental autoimmune encephalomyelitis

Todd S. Davidson and William F. Hickey1

Department of Pathology Borwell Building Dartmouth Medical School – DHMC Lebanon, NH 03756

1 Correspondence: Department of Pathology, DHMC Lebanon, NH 03756. E-mail: william.f.hickey{at}dartmouth.edu

Antisecretory factor (ASF) was originally identified as a potent inhibitor of intestinal fluid secretion induced by a number of enterotoxins. In addition to its involvement in intestinal fluid secretion, ASF modulates the proliferation of memory/effector T cells and is expressed by cells of the immune system. This report describes the role of ASF in modulating immune responses and assesses the regulation of ASF during an in vivo immunological reaction. ASF expression was redistributed during adoptively transferred experimental autoimmune encephalomyelitis (EAE), and in response to other inflammatory stimuli. Administration of the anti-ASF antibody TLD-1A8A increased the clinical severity and duration of the disease. Consistent with these findings, addition of TLD-1A8A to T cell proliferation assays resulted in up-regulation of the proinflammatory cytokines IL-18 and IL-6 and in down-regulation of IL-10. Furthermore, we identified cytokines that regulated the expression of ASF at both the mRNA and protein level. ASF, therefore, appears to play a previously unappreciated and potentially important role in the regulation of immune responses.

Key Words: macrophage • T lymphocyte • cytokine • immunosuppression






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