| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Published online before print June 14, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
T cells in the regulation of neutrophil-mediated tissue damage after thermal injury
Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham
1 Correspondence: The University of Alabama at Birmingham, Center for Surgical Research, Department of Surgery, G094 Volker Hall, 1670 University Blvd., Birmingham, AL 35294-0019. E-mail: schwacha{at}uab.edu
Thermal injury induces an inflammatory response that contributes to the development of secondary tissue damage. Neutrophil recruitment and activation are in part responsible for this tissue damage. Although 
T cells have been shown to regulate the inflammatory responses in tissues that are prone to neutrophil-mediated injury post-burn, their role in the induction of secondary tissue injury post-burn remains unknown. To study this, T cell-deficient ( TCR–/–) and wild-type (WT) mice were subjected to thermal injury or sham procedure, and tissue samples were isolated 1–24 h thereafter. Burn injury induced neutrophil accumulation in the lung and small intestines of WT mice at 1–3 h post-injury. No such increase in neutrophil tissue content was observed in TCR–/– mice. An increase in tissue wet/dry weight ratios was also observed in these organs at 3 h post-burn in WT but not in TCR–/– mice. A parallel increase in plasma and small intestine levels of the chemokines macrophage-inflammatory protein-1ß (chemokine ligand 4) and keratinocyte-derived chemokine (CXC chemokine ligand 1) were observed in injured WT mice but not in injured TCR–/– mice. Increased activation (CD120b expression) of the circulating T cell population was also observed at 3 h post-burn in WT mice. These results indicate the T cells, through the production of chemokines, play a central role in the initiation of neutrophil-mediated tissue damage post-burn.
Key Words: chemokine • CD120b • lung • small intestine • myeloperoxidase • liver • inflammation
This article has been cited by other articles:
|
|
 |
|
  F. Venet, C.-S. Chung, G. Monneret, X. Huang, B. Horner, M. Garber, and A. Ayala Regulatory T cell populations in sepsis and trauma J. Leukoc. Biol., March 1, 2008; 83(3): 523 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li, E. J. Kovacs, M. G. Schwacha, I. H. Chaudry, and M. A. Choudhry Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1193 - L1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hildebrand, W. J. Hubbard, M. A. Choudhry, B. M. Thobe, H.-C. Pape, and I. H. Chaudry Effects of 17{beta}-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females J. Leukoc. Biol., October 1, 2006; 80(4): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hildebrand, W. J. Hubbard, M. A. Choudhry, M. Frink, H.-C. Pape, S. L. Kunkel, and I. H. Chaudry Kupffer Cells and Their Mediators: The Culprits in Producing Distant Organ Damage after Trauma-Hemorrhage Am. J. Pathol., September 1, 2006; 169(3): 784 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Raspollini, F. Castiglione, D. Rossi Degl'Innocenti, G. Amunni, A. Villanucci, F. Garbini, G. Baroni, and G. L. Taddei Tumour-infiltrating gamma/delta T-lymphocytes are correlated with a brief disease-free interval in advanced ovarian serous carcinoma Ann. Onc., April 1, 2005; 16(4): 590 - 596. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
