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Originally published online as doi:10.1189/jlb.0404249 on June 14, 2004

Published online before print June 14, 2004
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(Journal of Leukocyte Biology. 2004;76:383-387.)
© 2004 by Society for Leukocyte Biology

APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients

Dale S. Gregerson1 and Hidetoshi Kawashima2

Department of Ophthalmology, University of Minnesota, Minneapolis

1Correspondence: Department of Ophthalmology, University of Minnesota, Lions Research Building, Rm. 314, 2001 6th Street, S.E., Minneapolis, MN 55455. E-mail: grege001{at}tc.umn.edu

T cell adoptive transfer models of autoimmune disease have been used in conjunction with radiation/bone marrow chimeras to define the minimal requirements for antigen (Ag) recognition. In models with central nervous system Ags, major histocompatibility complex (MHC) class II compatibility achieved by grafting F1 bone marrow into parental recipients was reported to be necessary and sufficient for transfer of CD4 T cell-mediated experimental autoimmune encephalomyelitis. Bone marrow-derived, perivascular microglia are now widely regarded to play a critical role in the expression of experimental autoimmune diseases of the nervous system. Similar results might be expected in the experimental autoimmune uveoretinitis model, as retina is an extension of the brain. Using an allogeneic Ag-presenting cell (APC) adoptive transfer strategy, it was found that resident APC were not essential and that their replacement with MHC-compatible cells by bone marrow-grafting techniques was not necessary. Instead, APC were recruited from the circulation.

Key Words: autoimmunity • antigen presentation • arrestin • uveoretinitis • T cells




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D. S. Gregerson, N. D. Heuss, K. L. Lew, S. W. McPherson, and D. A. Ferrington
Interaction of Retinal Pigmented Epithelial Cells and CD4 T Cells Leads to T-Cell Anergy
Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4654 - 4663.
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