| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Published online before print March 23, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
,
,
,¶,,¶,1
* Departments of Cell Biology, Neurobiology, and Anatomy and
¶ Surgery,
Immunology and Aging Program,
Burn and Shock Trauma Institute, Loyola University Chicago, Maywood, Illinois; and
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois
1Correspondence: Department of Cell Biology, Neurobiology, and Anatomy, Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Building 110, Room 4237, 2160 South First Avenue, Maywood, IL 60513. E-mail: ekovacs{at}lumc.edu
The innate immune system serves an important role in preventing microbial invasion. However, it experiences significant changes with advancing age. Among the age-associated changes are: Aged macrophages and neutrophils have impaired respiratory burst and reactive nitrogen intermediates as a result of altered intracellular signaling, rendering them less able to destroy bacteria. Aged neutrophils are also less able to respond to rescue from apoptosis. Aged dendritic cells (DC) are less able to stimulate T and B cells. The altered T cell stimulation is a result of changes in human leukocyte antigen expression and cytokine production, and lower B cell stimulation is a result of changes in DC immune complex binding. Natural killer (NK) cells from the elderly are less capable of destroying tumor cells. NK T cells increase in number and have greater interleukin-4 production with age. Levels of various complement components are also altered with advancing age.
Key Words: immunosenescence • macrophage • dendritic cell • polymorphonuclear neutrophil
This article has been cited by other articles:
|
|
 |
|
  T. Baas, A. Roberts, T. H. Teal, L. Vogel, J. Chen, T. M. Tumpey, M. G. Katze, and K. Subbarao Genomic Analysis Reveals Age-Dependent Innate Immune Responses to Severe Acute Respiratory Syndrome Coronavirus J. Virol., October 1, 2008; 82(19): 9465 - 9476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-F. Kong, K. Delroux, X. Wang, F. Qian, A. Arjona, S. E. Malawista, E. Fikrig, and R. R. Montgomery Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly J. Virol., August 1, 2008; 82(15): 7613 - 7623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Lages, I. Suffia, P. A. Velilla, B. Huang, G. Warshaw, D. A. Hildeman, Y. Belkaid, and C. Chougnet Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation J. Immunol., August 1, 2008; 181(3): 1835 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Albert and J. S. Marshall Aging in the absence of TLR2 is associated with reduced IFN-{gamma} responses in the large intestine and increased severity of induced colitis J. Leukoc. Biol., April 1, 2008; 83(4): 833 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Mathur, E. A. Schwantes, N. N. Jarjour, and W. W. Busse Age-Related Changes in Eosinophil Function in Human Subjects Chest, February 1, 2008; 133(2): 412 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. J. Signer, E. Montecino-Rodriguez, O. N. Witte, J. McLaughlin, and K. Dorshkind Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia Blood, September 15, 2007; 110(6): 1831 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Dublineau, L. Grandcolas, S. Grison, C. Baudelin, F. Paquet, P. Voisin, J. Aigueperse, and P. Gourmelon Modifications of Inflammatory Pathways in Rat Intestine Following Chronic Ingestion of Depleted Uranium Toxicol. Sci., August 1, 2007; 98(2): 458 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Hodkinson, M. Kelly, H. D. Alexander, I. Bradbury, P. J. Robson, M. P. Bonham, J. M. O'Connor, C. Coudray, J. J. Strain, and J. M. W. Wallace Effect of Zinc Supplementation on the Immune Status of Healthy Older Individuals Aged 55-70 Years: The ZENITH Study J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2007; 62(6): 598 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhao, L. Sun, H. Wang, H. Ma, G. Liu, and Y. Zhao Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice J. Leukoc. Biol., June 1, 2007; 81(6): 1386 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Murciano, E. Villamon, A. Yanez, J.-E. O'Connor, D. Gozalbo, and M. L. Gil Impaired immune response to Candida albicans in aged mice. J. Med. Microbiol., December 1, 2006; 55(Pt 12): 1649 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Hodkinson, J. M. O'Connor, H. D. Alexander, I. Bradbury, M. P. Bonham, B. M. Hannigan, W. S. Gilmore, J. J. Strain, and J. M. W. Wallace Whole Blood Analysis of Phagocytosis, Apoptosis, Cytokine Production, and Leukocyte Subsets in Healthy Older Men and Women: The ZENITH Study. J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2006; 61(9): 907 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Chelvarajan, Y. Liu, D. Popa, M. L. Getchell, T. V. Getchell, A. J. Stromberg, and S. Bondada Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages J. Leukoc. Biol., June 1, 2006; 79(6): 1314 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shimizu, R. N. Mitchell, and P. Libby Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 987 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sen, Q. Chen, and C. M. Snapper Immunization of Aged Mice with a Pneumococcal Conjugate Vaccine Combined with an Unmethylated CpG-Containing Oligodeoxynucleotide Restores Defective Immunoglobulin G Antipolysaccharide Responses and Specific CD4+-T-Cell Priming to Young Adult Levels Infect. Immun., April 1, 2006; 74(4): 2177 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Stout, C. Jiang, B. Matta, I. Tietzel, S. K. Watkins, and J. Suttles Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences J. Immunol., July 1, 2005; 175(1): 342 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Alignani, B. Maletto, M. Liscovsky, A. Ropolo, G. Moron, and M. C. Pistoresi-Palencia Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice J. Leukoc. Biol., June 1, 2005; 77(6): 898 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rai, G. Sacks, and G. Trew Natural killer cells and reproductive failure--theory, practice and prejudice Hum. Reprod., May 1, 2005; 20(5): 1123 - 1126. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
