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Published online before print February 13, 2004
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The William Harvey Research Institute, Bart’s and the London Queen Mary School of Medicine and Dentistry, Charterhouse Square, United Kingdom
1Correspondence: The William Harvey Research Institute, Bart’s and the London Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. E-mail: M.Perretti{at}qmul.ac.uk
This overview will focus on one aspect of neutrophil biology, which is the selective activation of the annexin 1 system in relation to the process of cell extravasation. Besides the current view about the biochemistry of annexin 1 and annexin 1 receptor(s) up-regulation within the microenvironment of the adherent neutrophils, we will also comment on the final result achieved by activation of the system, which is inhibition of neutrophil recruitment. In view of the historical link between annexin 1 and glucocorticoids, the potential for the annexin 1 system in mediating at least some of the anti-inflammatory actions of these powerful drugs is also discussed.
Key Words: glucocorticoids • anti-inflammation • lipocortin • adhesion • trafficking • endothelium
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